The smart Trick of ceesdekker That No One is Discussing

The smart Trick of ceesdekker That No One is Discussing

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‘Of course, that is about appropriate. I search for a Bodily idea of biological programs inside of a bottom-up way. I believe you could potentially distinguish three traces of investigate in my group in the intervening time. The first considerations chromosome framework: How does one obtain a metre-prolonged DNA polymer folded and organised in such a microscopic cell? We now have made visualisation techniques that enable us to review how, for example, SMC proteins loop DNA (video clip on Youtube) in an effort to build up chromosomes.

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[Laughs] ‘It had been undoubtedly a terrific threat! At time, I was nicely aware that it could go wrong Which I could come to be significantly less prosperous, but I just overlooked that. Curiosity has often been my strongest driving power. And luckily everything labored out.’

Sculpting nano-electrodes having a transmission electron beam for electrical and geometrical characterization of nanoparticles.

This yielded a breakthrough. In only a few months, we ended up in a position to evaluate transport by someone one-walled carbon nanotube. Depending on low-temperature experiments by an excellent PhD student in my group, Sander Tans (now a valued colleague and professor at Delft College of Engineering having an active exploration lab at AMOLF in Amsterdam), we showed that carbon nanotubes have been legitimate quantum wires with really extensive (micrometres) electronic coherence lengths — confirming theoretical predictions of metallic conduct.

Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of one wire bridging two electrodes

All parameters had been precisely the same for every panel During this video, except for the Preliminary placement in the 6hb rod (proven in blue) about the nanopore. Simulations that terminated early as a consequence of translocation of the rod throughout the pore are marked by a gray qualifications.

2011, to start with in vitro measurements of transportation throughout an individual biomimetic nuclear pore sophisticated; advancement of multiplexed magnetic tweezers for kilo-molecule experiments; and settled the mechanism of homology recognition in DNA homologous recombination

Let's say, as opposed to using regular best-down silicon electronics, transistors can be designed from the bottom up working with single natural and organic molecules because the switching features? This idea, which turned the basis of currently’s area of molecular electronics, initially emerged within the nineteen seventies.

Resolving the action dimensions in condensin-pushed DNA loop extrusion identifies ATP binding as being the action-making course of action

An integrated microfluidic System for quantifying drug permeation throughout biomimetic vesicle membranes

1999, initially ceesdekker.net measurement from the wavefunction of solitary molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive proof for the new Luttinger description of interacting electrons in nanotubes

2005, discovery from the system of DNA uncoiling by topoisomerase enzymes; discovery of long-selection conformational changes in Mre11/DNA mend complexes; and first pressure measurements with a DNA molecule inside a nanopore

‘I am driven by ponder and thoughts. On a material level I locate solutions in physics, but I practical experience my deepest contentment with God. That faith also drives my science and how I handle men and women.